Disseminated Intravascular
Coagulation and Excessive Fibrinolysis
(DIC XFL) Syndrome in Prostate
Cancer: A Rare Complicated Disorder
Published: January 1, 2017 | DOI: https://doi.org/10.7860/JCDR/2017/22582.9313
Azhar Bin Amir Hamzah, Yew Maw Choo, Mohamed Azmi Hassali, Fahad Saleem, Ashutosh Kumar Verma
1. Consultant Urology Surgeon and Senior Medical Lecturer, Urology Unit, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
2. Doctor, Urology Unit, Department of Surgery, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
3. Professor, Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
4. Senior Lecturer, Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
5. Masters (Research) Candidate, Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Correspondence
Dr. Mohamed Azmi Hassali,
Professor of Social and Administrative Pharmacy, School of Pharmaceutical Sciences,
Universiti Sains Malaysia, 11800 Penang, Malaysia.
E-mail: azmihassali@gmail.com
Disseminated Intravascular Coagulation (DIC) develops in patient with prostate cancer, which is manifested by systemic, intracranial, intracavitary or intracutaneous bleeding indicating uncompensated or excessive fibrinolysis (XFL). This case report is a description of a 61-year-old male with metastatic prostate cancer that progressed to manifest DIC. The condition is rare in clinical practice, and even rarer when is coupled with XFL. Treatment was mainly replenishing coagulation factors, platelets and controlling the disease progression with aggressive hormonal therapy. The patient progressed to coagulopathy further with fibrinolysis, hence leading to mortality. This case study discusses the pathophysiology of this complication and various methods to monitor the disease progression are discussed.
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